蝽卵金小蜂属一新种记述(小蜂总科:金小蜂科:柄腹金小蜂亚科)

本文记述金小蜂科柄腹金小蜂亚科蝽卵金小蜂属一新种,正模、配模、副模,采自北京市平谷县。     

Diminished social interaction incentive contributes to social deficits in mouse models of autism spectrum disorder

One of the core symptoms of autism spectrum disorder (ASD) is impaired social interaction. Currently, no pharmacotherapies exist for this symptom due to complex biological underpinnings and distinct genetic models which fail to represent the broad disease spectrum. One convincing hypothesis explaining social deficits in human ASD patients is amotivation, however it is unknown whether mouse models of ASD represent this condition. Here we used two highly trusted ASD mouse models (male Shank3‐deficient [Shank3^+/ΔC] mice modeling the monogenic etiology of ASD, and inbred BTBR mice [both male and female] modeling the idiopathic and highly polygenic pathology for ASD) to evaluate the level of motivation to engage in a social interaction. In the behavioral paradigms utilized, a social stimulus was placed in the open arm of the elevated plus maze (EPM), or the light compartment of the light‐dark box (LDB). To engage in a social interaction, mice were thus required to endure innately aversive conditions (open areas, height, and/or light). In the modified EPM paradigm, both Shank3^+/ΔC and BTBR mice demonstrated decreased open‐arm engagement with a social stimulus but not a novel object, suggesting reduced incentive to engage in a social interaction in these models. However, these deficits were not expressed under the less severe aversive pressures of the LDB. Collectively, we show that ASD mouse models exhibit diminished social interaction incentive, and provide a new investigation strategy facilitating the study of the neurobiological mechanisms underlying social reward and motivation deficits in neuropsychiatric disorders.     

瑞芬太尼复合丙泊酚麻醉对结肠癌手术患者血流动力学、炎症反应及免疫球蛋白的影响

目的:探讨瑞芬太尼复合丙泊酚麻醉对结肠癌手术患者血流动力学、炎症反应及免疫球蛋白的影响。方法:选取2017年1月～2018年12月期间于新疆医科大学附属第一医院行腹腔镜下结肠癌根治术患者189例,根据随机数字表法将患者分成对照组(n=94,丙泊酚麻醉)和研究组(n=95,瑞芬太尼复合丙泊酚麻醉),比较两组患者围术期指标、血流动力学、炎症反应及免疫球蛋白水平,记录两组术中不良反应发生情况。结果:研究组患者苏醒时间、拔管时间、自主呼吸恢复时间、定向力恢复时间均短于对照组(P0.05)。对照组麻醉诱导10 min(T2)、术毕拔管后10 min(T3)时间点心率(HR)、平均动脉压(MAP)较T1时间点降低,T3时间点高于T2时间点(P0.05),研究组T2时间点HR、MAP较T1时间点降低(P0.05);研究组T2、T3时间点HR、MAP高于对照组同时间点(P0.05)。研究组术后1h(T4)、术后1d(T5)时间点白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)低于对照组同时间点(P0.05)。研究组T4、T5时间点免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)、免疫球蛋白G(Ig G)高于对照组同时间点(P0.05)。两组不良反应发生率比较差异无统计学意义(P0.05)。结论:结肠癌手术中使用瑞芬太尼复合丙泊酚麻醉,可有效改善围术期各项指标,维持机体血流动力学稳定,减少机体炎症反应、免疫抑制,安全可靠。     

关节镜联合富血小板血浆对膝关节半月板损伤患者膝关节功能和生活质量的影响

目的:探讨关节镜联合富血小板血浆对膝关节半月板损伤患者膝关节功能和生活质量的影响。方法:选取2017年12月-2019年9月期间我院收治的膝关节半月板损伤患者80例,根据随机数字表法分为对照组(n=40)和研究组(n=40),对照组予以关节镜下修整手术治疗,研究组在对照组基础上联合富血小板血浆治疗,比较两组患者优良率、生活质量及视觉模拟评分量表(VAS)、Lysholm评分量表、美国西安大略和麦克马斯特大学关节炎指数(WOMAC)评分。记录两组治疗期间不良反应情况。结果:研究组治疗后3个月的膝关节功能优良率高于对照组(P0.05)。两组治疗前、治疗后1个月、治疗后3个月VAS、WOMAC评分均逐步降低,Lysholm评分逐步升高(P0.05);研究组治疗后1个月、治疗后3个月VAS、WOMAC评分低于对照组,Lysholm评分高于对照组(P0.05)。两组治疗后3个月SF-36各维度评分均较治疗前升高,且研究组高于对照组(P0.05)。两组不良反应发生率对比未见统计学差异(P0.05)。结论:关节镜联合富血小板血浆治疗膝关节半月板损伤患者,可促进膝关节功能的恢复,可有效缓解手术治疗后的疼痛症状,改善患者生活质量,具有较好的临床应用价值。     

白藜芦醇通过下调MEK/ERK/c-Jun信号通路抑制H2O2诱导的肺癌细胞增殖

目的:探讨白藜芦醇(Res)是否通过下调ERK激酶/胞外信号调节激酶/原癌基因(MEK/ERK/c-Jun)信号通路抑制小剂量过氧化氢(H2O2)诱导肺癌细胞增殖。方法:采用MTS实验检测小剂量20μM H2O2以及分别加入MEK阻断剂U0126和Res后H2O2对肺癌细胞NCI-H1395增殖的影响,采用Western Blot检测H2O2对ERK1/2和Akt蛋白磷酸化水平以及加入Res后H2O2对MEK、ERK1/2和c-Jun蛋白磷酸化水平的影响。结果:小剂量H2O2对肺癌细胞NCI-H1395具有促增殖作用,H2O2通过活化ERK1/2和Akt蛋白的磷酸化水平促进肺癌细胞NCI-H1395增殖,加入MEK阻断剂U0126后H2O2对肺癌细胞NCI-H1395增殖作用降低(P<0.05)。Res可抑制H2O2诱导的肺癌细胞NCI-H1395增殖,加入Res后,H2O2引起的MEK、ERK1/2和c-Jun蛋白磷酸化水平均降低(P<0.05)。结论:小剂量H2O2对肺癌细胞NCI-H1395具有促增殖作用,Res通过抑制MEK/ERK/c-Jun信号通路来抑制H2O2对肺癌细胞NCI-H1395的促增殖作用,其具体机制还需进一步研究。